Keywords
Abstract
Introduction. The problem of different responses to chemotherapy for tuberculosis remains one of the leading and not fully studied. Since the extracellular matrix is an important morphofunctional element in the implementation of the inflammatory response, including the specific one, the study of impaired homeostasis in it can shed light on the problem of ineffective therapy. The aim of the study was to evaluate the influence of the rs6707530 polymorphism of the fibronectin gene on the effectiveness of treatment of newly diagnosed pulmonary tuberculosis. Materials and methods. The study included 127 people with newly diagnosed pulmonary tuberculosis. At 2, 4 and 6 months of the study, bacteriological and radiological data were evaluated. Patients were divided into 2 groups depending on the effectiveness of the intensive phase of chemotherapy. Results. The groups were compared according to the clinical forms, the presence and type of drug resistance (DR) of the pathogen, the presence of comorbidities, the presence of bacteria and lung tissue, and the distribution of alleles and genotypes of the gene under study. Conclusion. We came to the conclusion about the possible influence on the outcome of the treatment of the presence of wide drug resistance of the pathogen, bacterial secretion and lung tissue breakdown at the time of admission, as well as mutations in the rs6707530 locus of the FN1 gene. In particular, the carriage of the G allele and the G/G genotype is associated with a higher capacity for repairing lung tissue.