Partial agonists of nicotinic receptors in treatment of dependence on tobacco

Abstract

Various methods are use for smoking cessation. To facilitate refusal of smoking, various methods are used. Despite a wide circulation a nicotine replacement therapy, application of partial agonists of nicotinic receptors (varenicline and cytisine) is represented to more perspective. Varenicline and cytisine have a series of differences on a pharmakokinetics, a pharmacodynamics, restrictions on application. Direct comparison of cytisine and vareniklin wasn’t carried out. Pharmacological properties of preparations and their possible influence on therapeutic effects are discussed.