Research of level of a neopterin at different forms of tubercular inflammatory process

Abstract

Activation of cells of immune system reflects increase of temperament of infectious process at tuberculosis of lungs. One of the reasons of it is neopterin. Synthesis of a neopterin causes still strengthening of work of macrophages. The purpose of this research patients have a studying of concentration of a neopterin with different forms of tubercular process, different prevalence, different medicinal stability of the activator. Investigated blood of 124 people. The first group - 31 persons - had a limited form of tubercular inflammatory process (tuber- culoma), the second group - 44 persons - had infiltrative tuberculosis, the third group - 24 persons - there was with fibrous-cavernous pulmonary tuberculosis, the fourth group - 25 people - almost healthy people. Patients with tuberculoma had an active phase or a phase of the abating or moderate activity. Patients with infiltra- tive tuberculosis had defeat of 1-3 segments of fabric or4 and more segments. Average age of examinees made 34.0±2.5 years. Determination of concentration of a neopterin is executed by an enzyme-linked immunosorbent assay (IBL international, Hamburg Germany). Statistical data processing is carried out with use of the Microsoft Office Excel 2007 and Statistica for Windows v.6.1 programs. It was established that at patients from tuberculoma neopterin increased slightly - by 13.3% in comparison with group of healthy faces, at patients with infiltrative tuberculosis - for 57.1%, at patients with fibrous-cavernous pulmonary tuberculosis for 38.1%. Prevalence of process had on change to concentration of a neopterin small impact. Investigating concentration of a neopterin at patients from tuberculoma of various phase of activity, it was established that the active phase is followed by increase in concentration of a metabolite by15%, and the abating and moderate phase of activity of a tuberculoma - increase by 12%. Monitoring of level of a neopterin actually for determination of severity and activity of an infectious disease, dynamics of its current.