Keywords
Abstract
Pulmonary emphysema and its subtypes can be defined by visual assessment on high-resolution computed to- mography (HR-CT); however, features of lung structural changes on CT in patients with lung tuberculosis in com- bination with chronic obstructive pulmonary disease and their influence on lung function are not well defined. 117 patients with lung tuberculosis were observed. 23 pa- tients had lung tuberculosis in combination with chron- ic obstructive pulmonary disease (COPD), 94 patients were without COPD or other respiratory diseases. HR-CT performed and evaluated for specific changes and em-physema, and spirometry before and after bronchodila- tation, body plethysmography, diffusing capacity of the lung for carbon monoxide were measured. Compared with patients without COPD, individuals with COPD had greater widespread of specific changes and greater vol- umes of specific focus and destruction. Expressiveness of emphysematous changes was authentically higher in patients with COPD, the mixed and panlobular subtypes were prevailed. The greatest volume of emphysematous changes was in patients with the heaviest subtype of em- physema - panlobular. The increase of emphysematous changes had more expressed negative impact on lung function: airways disorders worsened not only at the forced exhalation, but also at quiet breath, the vital ca- pacity was decreased, the hyperinflation increased, pul- monary gas exchange worsened.