Keywords
Abstract
We studied the reparative osteogenesis features during the application of Osteoset-T in the substitution of bone OsteoSet-Tdefects of 12 rabbits on the experimental model of tuberculate ostitis, caused by the standard strain of M. tuberculosis Erdman, sensitive to antitubercular medicaments. We performed the comparative analysis of the results of Osteoset-T and autologous bone plasty. The effectiveness of the method was evaluated 1 month after the surgery according to the data of the X-ray and histology of the bone tissue sections.The comparison of the Osteoset-T and autologous bone plasty shows that the former one leads to the decrease of specific inflammation activity and stimulates the reparative osteogenesis. The X-ray examination of the animals with the Osteoset-T plasty shows the decrease of the specific inflammation activity, resolution of the plastic material the growth of a new bone in the zone of performed surgery.Pathomorfological study shows the decrease of inflammatory and dystrophic changes of the bone in the zone of performed plasty, the increase of new osteoid tissue growth with different differentiation degree, the increase of bone bar growth and the activation of megakaryocytic and myeloid sprouts of medullar hematopoiesis.