Keywords
ЛЕКАРСТВЕННАЯ РЕЗИСТЕНТНОСТЬ, DRUG RESISTANCE, МИКОБАКТЕРИИ ТУБЕРКУЛЕЗА, ТУБЕРКУЛЕЗ ЛЕГКИХ, PULMONARY TUBERCULOSIS, ВНЕЛЕГОЧНЫЙ ТУБЕРКУЛЕЗ, EXTRAPULMONARY TUBERCULOSIS, ВИДЫ РЕЗИСТЕНТНОСТИ, TYPES OF RESISTANCE, ЧАСТОТА И СТРУКТУРА, FREQUENCY AND STRUCTURE, МЕХАНИЗМЫ РАЗВИТИЯ, DEVELOPMENT MECHANISMS, МЕТОДЫ ОПРЕДЕЛЕНИЯ, DEFINITION METHODS, TUBERCULOSIS MICOBACTERIA
Abstract
In the lecture are stated the types of drug resistance (DR) of MBT - primary and secondary, the frequency and structure of DR - monoresistance, polyresistance, multiple DR (MDR), extremal DR (XDR), total DR and a technique of their measurement. There are presented methods of MBT DR testing - cultural, including accele rated, and molecular genetic ones. Mechanisms of DR de- velopment by MBT, close association of resistance strains and their belonging to the Beijing genetic family are de- scribed. There is shown frequency and structure of MBT DR in relation to the various TB localizations and dange- rous tendencies in such of steady increase with growing severity of its structure.