Evaluation of pharmacokinetic parameters and toxicity of anti-tuberculosis drug based on oxidized dextran and the hydrazide of isonicotinic acid

Abstract

The article presents the results of pre-clinical studies of antituberculosis drug based on oxidized dextran and the hydrazide of isonicotinic acid. As results of conducted study pharmacokinetic characteristics and parameters of acute toxicity of developing drug were determined. After single intraperitoneal and intravenous administration dextrazide showed greater toxicity compared with INH as evidenced by the mortality of animals, the manifestations of the responses from the neuro-muscular and cardiovascular systems (clonic convulsions, ataxia, hyper - and hypokinesia, foam). At the same time the drug had no toxic effects on integral indicators of the majority of the survived experimental animals.