Predictors of unfavorable course and outcome of infiltrative pulmonary tuberculosis

Abstract

A comprehensive statistical analysis of medical history, clinical and radiographic features of the disease and the results of treatment of 300 patients with newly diagnosed infiltrative pulmonary tuberculosis (the main group of 150 patients, with unfavorable outcomes of disease, comparison group: 150 patients, with favorable outcome) allowed to identify several groups of factors (predictors) influencing the efficiency of treatment and outcome in these category of patients. These include: organizational (late detection of the disease) associated with the peculiarities of the current process (the prevalence of the process, the presence of decay cavities, MBT DR), social (the presence of family, work, educational level, alcohol abuse), personality (low adherence to treatment) biomedical (comorbidities, state reactivity).