Keywords
Abstract
The immune system was studied on the example of the blood levels of cytotoxic lymphocytes, such as cytotoxic T lymphocytes and NK- cells in patients with COPD stage 2 (37 patients) in the stage of exacerbation and remission, and healthy controls ( 24 men ), making the comparison group. Methods of indirect immunofluorescence was determined relative and absolute content of peripheral blood lymphocytes expressing the antigens CD3, CD4, CD8, CD16, CD20, CD23, CD25, CD54, CD71, CD72, HLA-DR, CD95, and membrane immunoglobulin smIgM mIgG. The study proved that patients with COPD had a significant increase in the blood levels of cytotoxic lymphocytes, regardless of the stage of disease (p <0,001). During an exacerbation of COPD in the serum of patients significantly increases the number of CD4, CD8, CD20, CD72, NK- cells, mIgG +- lymphocytes and mIgM + lymphocytes, without exacerbation normalized level CD20, CD72, however, the number of other cytotoxic cells remains high, supports progressive inflammation and tissue damage lungs and bronchi.