Abstract
Retrospective clinical and laboratory data analysis of 115 patients with widespread tuberculosis spondylitis treated in 2008-2012 is presented. Drug resistant (DR) Mycobacterium tuberculosis strains were found in 73,0% of all patients, 87,5% in HIV-positive patients and 69,2% - in HIV-negative group. HIV-positive patients are more likely had additional TB loci in lungs and thoracic lymph nodes. Frequency of active tuberculosis process in lungs additionally to spondylitis was 9 times higher in HIV-positive patients, compared to HIV-negative group. The risk of multy drug resistance in immunocompromised patients was 2.45 times higher than in HIV-negative patients. The presence of DR in M. tuberculosis isolated from patients with tuberculosis spondylitis is a risk factor for spinal cord disease generalization (OR=3.11);