Metabolic bone diseases in patients with tuberculous spondylitis and HIV infection

Abstract

The present article analyzes the results of the IOF one- minute osteoporosis risk test, dual energy x-ray asbsorciometry and biochemical bone turnover markers in 20 patients with HIV infection and tuberculosis spondylitis (group 1) and compares them with the results in 20 patients with spinal tuberculosis and HIV-negative status (group 2). According to the results of the IOF test, there is a high risk of bone fracture due to osteoporosis in group 1 patients. The combination of HIV infection and spinal tuberculosis contributes to a threefold decreased bone mineral density in relation to patients with tuberculous spondylitis without HIV infection. Bone turnover markers and results of bone mineral density measurements in patients with HIV infection and spinal tuberculosis do not depend on the level of immunodeficiency according to the CD4+ T-cell count.