An objective approach to the formulation of the main pathologic diagnosis based on the histomorphological features of deceased patients with co-infection (HIV/TB)

Abstract

Among patients with advanced HIV infection, TB is a leading cause of death. According to some authors co-infected patients' death of tuberculosis may occur not in advanced, but also in early stages of HIV-infection (1-3th stages by V.V. Pokrovsky). In clinical practice to identify the stage of HIV infection it is not possible for technical reasons (for a short time in hospital, and the lack of data on the prescription of HIV infection). The purpose of the study to objectify approach to the formulation of the main pathologic diagnosis based on histomorphological signs.34 studied the history and protocol of opening 2011, theGroup formed by the main findings at diagnosis. In Group1 are combined observation, where the main pathologic diagnosis of tuberculosis is exposed, the 2nd - HIV infection. It analyzed 12 histomorphological signs with co-infection (HIV-TB). Applying discriminant analysis, canonical function is formed. The study formed new clusters «TB»and «HIV» on the basis of categories histomorphological signs. No significant differences in the clinical forms of tuberculosis and secretion MBT received. Statistical differences concerned the histologic features: cheesy necrosis shaft specific cells, leukocyte infiltration, the presence of fibrin, decay or cavity. On the basis of the presence or absence of these features offered canonical function, a positive value which allows to give the definition of the main priorities in the postmortem diagnosis of tuberculous process, the negative - HIV infection.

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