Abstract
Introduction. The article contains the results of female patients’ immune system autoreactivity prior and after breast surgeries, as well as dynamic 6-years’ follow-up. Two groups of patients have been under study: in the first group breast surgery was done with silicone implants according to aesthetic and reconstructive recommendations; while in the second group various breast surgeries were performed, but no implants were used. In the result, it was shown that 92 % of patients with silicone implants had increased and even pathological level of thyrotropic hormone antibodies (TSHR-Ab) by month 6 after the implantation, and this increased level was preserved for 1 year. No such phenomena have been seen in the group of patients without the implants. 6 years after the implantation only 4% of patients still maintained such changes. Besides, the authors paid attention to the impact of dental implants and HLA_B27 on the level of annexin V antibodies. Тhus, after the initial increase of autoreactivity the patient’s body adjusts to silicone implants and autoreactivity is back to normal, which complies with R.M.Bayevsky’s pre-nosological state theory.