Abstract
Background. The role of melatonin in many physiological processes has been actively discussed for the last decade. The neuroendocrine hormone melatonin not only transmits information about the light cycle of the environment, but also actively participates in human reproductive ability. The discovery of melatonin synthesis in pineacytes of the epiphysis, and other cells such as Purkinje cells in the cerebellum, T lymphocytes, and NK cells marked the beginning of the definition of a new approach to the regulation of homeostasis and the creation of neuroimmunoendocrinology. Researchers often observe changes in the secretion of melatonin levels in various sleep disorders, depression, stress, some forms of cancer, as well as in impaired sexual development during puberty. Most of the circulating melatonin is metabolized in the liver to 6-hydroxymelatonin, then to 6-sulfatoxymelatonin, which is excreted in the urine. Aim. The quantitative content of melatonin sulfate (6-hydroxymelatonin sulfate) in the urine of women of early reproductive age with tuberculosis was analyzed. Materials and methods. A prospective comparative study based on the materials of the Department of Pulmonary Tuberculosis Therapy No. 1 of the. State Research Institute of Phthisiopulmonology: 29 patients of early reproductive age from 18 to 35 years old were examined and divided into 2 groups. The main group (n=11) with pulmonary tuberculosis and the control group (n=18) with women of early reproductive age who did not have tuberculosis. The women of the main and control groups were surveyed and the determination of melatonin sulfate by enzyme immunoassay was carried out. Results. No changes gave been detected in the melatonin sulfate secretion in the course of comparative analysis of the main and control groups (р ?0.001).
Conclusion. Melatonin sulfate synthesis in the group with pulmonary TB depended on the form and severity of the disease.